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多草药配方 (Imusil) 对循环胺诱导的实验动物模型的免疫调节作用

Ratheesh M¹, Sheethal S¹, Svenia P Jose¹

¹Department of Biochemistry, St. Thomas College, Palai, Kottayam, Kerala, India.

Asian Pacific journal of cancer prevention : APJCP

|November 29, 2023

概括

伊穆西尔 (IM) 通过刺激免疫反应并提供抗氧化剂和肝脏保护,有效地抵消化疗引起的免疫抑制. 这种多草药配方在恢复免疫平衡方面显示出显著的潜力.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
自然产品研究自然产品研究

背景情况:

化疗,如环胺 (CP),往往导致显著的免疫抑制,增加感染风险.
开发有效的免疫调节剂对于支持接受化疗的患者至关重要.

研究的目的:

在循环胺 (CP) 诱导的免疫抑制模型中评估多草药配方Imusil (IM) 的免疫调节作用.
评估IM恢复免疫功能和减轻CP诱导毒性的潜力.

主要方法:

使用动物模型,组接受正常控制,仅使用CP,使用levamisole (标准药物) 的CP,或使用IM的CP.
评估了免疫器官指数,肝酶,抗氧化剂,血液学,细胞因子平衡 (Th1/Th2),T淋巴细胞子集,并进行了他的病理学分析.

主要成果:

IM治疗显著逆转了CP诱导的免疫抑制,对免疫反应产生了积极的影响.
IM保护了免疫器官,增强了细胞介导和幽默免疫力,并增强了抗氧化活性.
IM 证明了针对 CP 诱导的肝毒性的肝保护作用,没有不良的血液学变化.

结论:

伊穆西尔 (IM) 通过刺激免疫系统,有效地抵消化疗引起的免疫抑制.
IM具有显著的抗氧化和肝脏保护性质,使其成为支持性治疗的有希望的药物.

关键词:

细胞因子 (cytokines) 是一种细胞因子.草药是一种草药.免疫反应是免疫反应.免疫调节剂是一种免疫调节剂.抗氧化剂抗氧化剂是一种抗氧化剂.

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