一项分析研究,以确定辐射诱导的甲状腺功能低下症的剂量-体积值
Kumar Pravesh1, Pooja Sethi1, Sadish Kumar Kamalanathan2
1Department of Radiation Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Asian Pacific journal of cancer prevention : APJCP
|November 29, 2023
概括
甲状腺的辐射剂量值,特别是28 Gy以下的平均剂量 (Dmean) 和49%以下的V40,可以帮助预防部辐射后癌症患者的辐射诱导的甲状腺功能低下症 (RIHT).
科学领域:
- 辐射瘤学 辐射瘤学
- 内分泌学 在内分泌学.
- 医学物理 医学物理
背景情况:
- 用于癌症治疗的部辐射可以导致辐射诱导的甲状腺功能低下症 (RIHT).
- 确定可预测剂量-体积值对于减轻这种副作用至关重要.
研究的目的:
- 确定辐射剂量-体积值,以预测癌症患者部辐射后的甲状腺功能低下症.
- 确定与RIHT发展相关的风险因素.
主要方法:
- 对120名接受部辐射 (3D-CRT或IMRT) 的癌症患者进行横截面后续研究.
- 放射治疗后进行的甲状腺剂量体积分析 (至少六个月的随访).
- 分析包括甲状腺平均剂量 (Dmean) 和接受40 Gy (V40) 的体积.
主要成果:
- 40%的患者出现RIHT (25.8%的临床,14.2%的亚临床).
- 显著的RIHT风险因素包括Dmean>28 Gy,V40>49%,年龄<50岁.
- 甲状腺功能低下的发作在辐射后大约两年达到顶峰.
结论:
- 甲状腺Dmean <28 Gy和V40 <49%是预防RIHT的潜在剂量-体积值.
- 这些值可以帮助优化放射治疗计划,以减少甲状腺功能低下的风险.
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