与日本抗菌药物使用的地理差异相关的因素
Taito Kitano1, Shinya Tsuzuki2,3,4, Ryuji Koizumi5
1Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD, 21205, USA.
日本抗菌药物使用 (AMU) 的地理差异与女性的比例,高等教育水平和上呼吸道感染 (URI) 诊断有关. 这些因素突出了改善抗微生物药物管理的潜在领域.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 抗菌药物使用 (AMU) 的地理差异尚不清楚.
- 了解这些变异对于优化抗菌药物管理计划至关重要.
- 这项研究调查了影响日本各县AMU差异的因素.
研究的目的:
- 评估与日本每1000名居民每天使用抗微生物药物的地理变异相关的因素.
- 在县级确定AMU的人口,教育和健康相关预测因素.
主要方法:
- 一项利用2019年日本国家数据库数据的观测生态研究.
- 每天每1000名居民的确定的每日剂量作为主要结果指标.
- 采用多变量负双项回归分析,结合患者和医生级别的变量.
主要成果:
- 分析了47个县的2019年的AMU总量.
- 在总AMU和女性个体的比例,高等中学教育程度和上呼吸道感染 (URI) 的发生率之间发现了显著的正相关性.
- 调整后的比率表明,每增加1%的女性人口,AMU增加4%,高等教育毕业生增加1%,每1000名居民增加21%的URI诊断.
结论:
- 日本AMU总数的县区差异与人口 (女性比例),社会经济 (教育水平) 和与健康有关的 (URI诊断) 因素有关.
- 这些发现表明需要有针对性的抗微生物管理干预措施,特别是为了减少可能不必要的URI抗微生物处方.
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