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种族和民族居住隔离和单细胞DNA甲基化年龄加速

Margaret T Hicken¹, John Dou², Kiarri N Kershaw³

¹Institute for Social Research, University of Michigan, Ann Arbor.

JAMA network open

|November 29, 2023

概括

邻居贫困和隔离与更快的生物衰老有关,特别是在黑人社区. 这些表观基因组变化可能解释了不利环境如何影响健康和慢性疾病.

科学领域:

环境健康环境健康
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
社会流行病学社会流行病学

背景情况:

邻居隔离和贫困是健康差异的公认驱动因素.
表观遗传学因素,如DNA甲基化时钟,越来越多地涉及到将社会决定因素与健康结果联系起来.
DNA甲基化钟可以作为生物衰老和生理失调的生物标志物.

研究的目的:

调查邻居隔离和贫困与DNA甲基化年龄加速之间的关联.
检查四种不同的DNA甲基化时钟,反映时间年龄或生理失调,是如何受到这些社会因素的影响.

主要方法:

这项研究利用了来自动脉样硬化多民族研究 (MESA) 的数据,这是一个纵向队列.
邻里贫困和隔离数据与2000年人口普查的参与者地址联系在一起.
在第5次检查 (2010-2012) 中测量了DNA甲基化,并使用四个不同的甲基化钟计算了年龄加速. 用线性回归模型进行分析.

主要成果:

在非西班牙裔黑人参与者中,增加的隔离与GrimAge DNA甲基化年龄加速有关 (每SD增加0.42年).
这种关联在高贫困地区更为明显.
总的来说,人口普查区的贫困与GrimAge DNA甲基化年龄加速 (β=0.45) 有关.

结论:

表观遗传学机制,特别是DNA甲基化和年龄加速,可能会调解邻居的劣势与健康之间的关系.
这些发现突出了邻居环境在塑造生物衰老和可能导致慢性疾病的作用.

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