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饮食因素与食道疾病之间的因果关系:孟德尔的随机化研究
Menglong Zou1,2, Qiaoli Liang3, Wei Zhang1,2
1The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
PloS one
|November 29, 2023
概括
饮食习惯会影响食道健康. 生蔬菜可以防止GERD,而干果摄入量与较低的食道癌症风险有关. 需要进一步的研究.
科学领域:
- 营养流行病学 营养流行病学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 调查饮食和食道疾病 (如GERD,BE和EC) 之间的因果关系对于公共卫生至关重要.
- 门德尔随机化 (MR) 提供了一个强大的方法,可以从观测数据中推断因果关系.
研究的目的:
- 确定特定的饮食因素与胃食道逆流性疾病 (GERD),巴雷特食道 (BE) 和食道癌 (EC) 的风险之间的因果关系.
主要方法:
- 利用了来自英国生物库的18种饮食摄入量的全基因组关联研究 (GWAS) 数据以及来自FinnGen.的食道疾病数据.
- 采用单变量和多变量门德尔随机化 (MR) 分析来评估因果关系.
- 结果使用几率比率 (OR) 和95%置信区间 (CI) 来量化.
主要成果:
- 生蔬菜摄入量与GERD有保护性关联 (OR=0.478),而煮熟的蔬菜增加了GERD风险 (OR=1.911).
- 面包摄入与更高的BE概率 (OR=6.754) 有关,而加工肉类摄入与降低的BE风险 (OR=0.210) 有关.
- 增加干果摄入量 (OR=0.087) 和添加到食品中的盐 (OR=0.346) 与较低的EC风险相关,尽管盐效应是由干果介导的.
结论:
- 饮食模式,包括蔬菜和干果的消费,显示了与GERD,BE和EC的因果关系.
- 具体发现表明生蔬菜和干果的保护作用,而面包和加工肉类则需要进一步调查与BE.
- 了解这些饮食因果关系对于制定针对食道疾病的有针对性的预防策略至关重要.
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