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Updated: Jul 9, 2025

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
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Cas9主要与人类的DNA断裂传感和修复系统直角

Ekaterina A Maltseva1, Inna A Vasil'eva1, Nina A Moor1

  • 1SB RAS Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.

PloS one
|November 29, 2023
PubMed
概括

基因编辑工具CRISPR/Cas9功能独立于人类DNA修复系统. Cas9有效地屏蔽了DNA断裂的修复传感器,表明其与细胞修复机制的正交.

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