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Updated: Jun 17, 2026

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
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在7q11.23神经发育障碍中,GTF2I剂量调节神经元分化和社会行为

Alejandro López-Tobón1,2,3, Reinald Shyti1,2, Carlo Emanuele Villa1,2

  • 1Department of Experimental Oncology, European Institute of Oncology IRCCS, Via Adamello 16, 20139 Milan, Italy.

Science advances
|November 29, 2023
PubMed
概括

在7q11.23中拷贝数的变化会影响大脑发育. 重复导致自闭症谱系障碍 (ASD) 通过影响神经前代细胞,与GTF2I基因相关的过程,并可能通过准LSD1.1.治疗.

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