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作为潜在的抗阿尔茨海默氏症剂的新型 styryl-thiazole 杂交物

Niki Gouleni1, Annalisa Di Rienzo2, Ahmet Yılmaz3

  • 1Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens Athens Greece.

RSC medicinal chemistry
|November 29, 2023
PubMed
概括

新型 styryl-thiazole 杂交物被开发用于阿尔茨海默病 (AD) 治疗. 化合物6i表现出显著的神经保护作用,抑制了乙胆酶 (AChE),并阻止了粉样β (Aβ) 聚合,显示出AD治疗的前景.

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