在比斯卡亚完成潜在结核病感染治疗:治疗方案和监测方法之间的差异
N Ortiz Laza1, I Lopez Aranaga1, J Toral Andres2
1Pulmonology Service, Cruces University Hospital, Biocruces-Bizkaia Health Research Institute, Barakaldo, Spain.
Frontiers in medicine
|November 29, 2023
概括
通过3HR方案和护士远程监控,潜在结核病感染 (LTBI) 治疗完成率得到改善. 这种方法通过在现实环境中增加坚持和成功的结果来加强结核病控制.
科学领域:
- 公共卫生 公共卫生
- 传染病流行病学 传染病流行病学
- 药物治疗 药物治疗
背景情况:
- 潜伏性结核病感染 (LTBI) 治疗对于低发病率国家的结核病 (TB) 控制至关重要.
- 巴斯克国家的综合性结核病控制计划利用护士病例经理和电子记录.
- 世界卫生组织批准的LTBI疗法包括6个月的异化 (6H),4个月的利芬素 (4R) 和3个月的异化-利芬素 (3HR).
研究的目的:
- 评估不同预防方案的LTBI治疗完成和毒性.
- 评估各种预防性治疗监测策略的遵守情况.
- 在现实临床环境中确定影响LTBI治疗成功的因素.
主要方法:
- 一项多中心回顾性队列研究分析了从2003年到2022年与LTBI接触的3066名结核病患者的数据.
- 与之比较的治疗方案是6H,4R和3HR.
- 护士病例经理远程监控从2016年开始实施,涉及电话跟踪和电子监控分发的药物.
主要成果:
- 总体而言,LTBI治疗完成率为66.8%.
- 3HR疗程的完成率 (86.5%) 与6H (68.3%) 相比显著更高.
- 护士远程监控与改善完成率 (85%) 与标准护理 (67%) 相关.
结论:
- 3HR疗法耐受性良好,并促进更高的LTBI治疗完成率.
- 护士带领的远程监控显著提高了治疗坚持和完成率.
- 这些发现支持将护士远程监测整合到结核病控制计划中,以改善患者的治疗结果.
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