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基于的合金具有适应的接口,用于骨植入物和组织工程.

Iulian Antoniac1,2, Veronica Manescu Paltanea1,3, Aurora Antoniac1

  • 1Faculty of Material Science and Engineering, National University of Science and Technology POLITEHNICA Bucharest, 060042 Bucharest, Romania.

Regenerative biomaterials
|November 29, 2023
PubMed
概括

合金提供生物相容的骨植入物,但需要表面调以控制腐蚀. 本综述详细介绍了基于的植入物用于骨修复和再生的挑战和进展.

关键词:
基于Mg的合金.适应的接口.骨组织工程 骨组织工程骨折的愈合 骨折的愈合表面的修改 表面的修改

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科学领域:

  • 生物材料科学 生物材料科学
  • 整形外科手术 整形外科手术
  • 组织工程是组织工程.

背景情况:

  • (Mg) 合金由于其生物降解性和生物相容性,对骨植入物具有前景.
  • 它们的机械性能与人类骨非常相似.
  • 在生理环境中的腐蚀需要表面修改或合金.

研究的目的:

  • 审查骨修复和再生的临床挑战.
  • 分析基于的植入物用于创伤和再生应用.
  • 探索控制Mg合金腐蚀和细胞相互作用的方法.

主要方法:

  • 对临床挑战,骨缺陷分类和治疗方法的文献综述.
  • 对Mg植入物机械性能和降解的体外和体内研究的分析.
  • 检查制造技术,植入物设计和表面修改技术.

主要成果:

  • 基于Mg的植入物,如板,螺丝和支架,用于各种骨缺陷治疗.
  • 植入物降解,释放气和新的骨形成是关键的界面挑战.
  • 表面修改,物理沉积和化学涂层可以提高植入物性能.

结论:

  • 合金对骨植入物具有重大潜力,但腐蚀仍然是一个挑战.
  • 先进的表面工程对于优化基于Mg的植入物集成和功能至关重要.
  • 对于转化应用和改善骨再生结果,需要进一步的研究.