环素D1和Ki-67的表达及其与宫性淋巴结转移在口腔状细胞癌的组织病理参数和宫性淋巴结转移的相关性
Saeedeh Khalesi1, Laleh Maleki2, Shahnaz Eskandari3
1Dental Material Research Center, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran.
Dental research journal
|November 29, 2023
概括
环素D1的表达是宫淋巴结转移在口腔状细胞癌 (OSCC) 的有用预测剂. 这项研究比较了OSCC患者的cyclin D1和Ki-67标志物,有和没有转移.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 生物标志物 生物标志物
背景情况:
- 口腔状细胞癌 (OSCC) 是一种普遍存在的口腔癌.
- 环素D1和Ki-67是细胞分裂的标记物.
- 研究这些标记物在OSCC转移中的作用至关重要.
研究的目的:
- 为了比较OSCC中与宫淋巴结 (LN) 转移的和没有宫淋巴结 (LN) 转移的cyclin D1和Ki-67表达.
- 评估这些标志物在OSCC的预后价值.
主要方法:
- 一项对40例OSCC病例 (20例具有LN转移,20例没有转移) 的横截面研究.
- 对包括淋巴血管侵袭 (LVI) 和围神经侵袭 (PNI) 在内的组织病理参数的评估.
- 针对环素D1和Ki-67进行免疫组织化学染色,然后进行统计分析.
主要成果:
- 根据LVI和疾病阶段发现了显著的相关性 (P < 0.001).
- 循环素D1表达在两组之间显示出显著的差异 (P = 0.05).
- 基-67表达根据瘤位置和PNI显著不同 (P = 0.026,P = 0.033).
结论:
- 环素D1是预测OSCC宫LN转移的一个有价值的标志物.
- 这些标记应考虑OSCC预后评估.
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