免疫系统和自闭症之间的遗传关系
Martina Arenella1,2,3, Giuseppe Fanelli2,3,4, Lambertus A Kiemeney5
1Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Brain, behavior, & immunity - health
|November 29, 2023
概括
自闭症谱系障碍 (ASD) 和免疫系统疾病之间的遗传联系表明,一些免疫因素会增加ASD风险,而其他因素可能会提供弹性. 这些联系是特定于某些遗传区域和自闭症特征,如刚性.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
- 神经发育障碍 神经发育障碍
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,具有重要的遗传成分.
- 新出现的证据表明,免疫失调在ASD病理生理学中起作用,但具体的遗传联系仍然不清楚.
研究的目的:
- 调查ASD与各种免疫条件和标记物之间的遗传相关性.
- 为了确定免疫相关的遗传因素是否与特定的自闭症类特征有关.
主要方法:
- 用全基因组关联研究 (GWAS) 总结统计数据来估计ASD和11种免疫表型之间的遗传相关性.
- 免疫表型的多基因分数 (PGS) 在人口样本中计算,并与自闭症类特征相关.
- 进行了性别分层分析.
主要成果:
- 在全基因组范围内,自闭症与过敏性疾病 (ALG) 有积极的遗传相关性,与淋巴细胞数量,类风湿性关节炎 (RA) 和全身性红斑狼 (SLE) 有负相关性.
- 当地遗传分析显示了ASD和RA,C-反应蛋白和粒细胞/淋巴细胞计数之间的相关性.
- 对SLE,RA,ALG和淋巴细胞水平的更高遗传责任与自闭症特征的增加有关,特别是刚性和童年行为.
结论:
- 在ASD和免疫之间存在显著的遗传关系,因免疫表型而异.
- 某些免疫遗传因素可能会增加ASD风险,而其他因素可能会赋予弹性.
- 遗传链接是特定于位置的,并且与自闭症的特定维度有关,例如刚性.
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