在患有慢性病的人群中,动脉硬度与自主功能障碍的测量之间的关联
Rachelle Davies1, Natasha Wiebe1, Andrew Brotto2
1Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, Canada.
Canadian journal of kidney health and disease
|November 29, 2023
概括
自主神经系统 (ANS) 功能障碍和血管硬与慢性病 (CKD) 有关. 系统性浸泡,衡量ANS功能的指标,与动脉-辐射脉冲波速相关,表明CKD患者的动脉硬.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 身体生理学 身体生理学
背景情况:
- 自主神经系统 (ANS) 功能障碍和血管硬是慢性病 (CKD) 患者心血管风险的重要因素.
- 已知较高的同情活动会增加动脉硬,但在CKD的背景下,这种关系仍未得到充分研究.
- 了解这些联系对于管理CKD中心血管并发症至关重要.
研究的目的:
- 调查自主功能测量和中度至重度CKD患者的动脉硬之间的关联.
- 为了确定特定的ANS标志物是否可以预测这种患者群体的动脉硬性.
主要方法:
- 一项随机对照试验的二次分析,该试验涉及44名中度至严重的CKD患者.
- 测量包括24小时的门诊血压,动脉-动脉和动脉-辐射脉冲波速度 (PWV),以及运动后心率恢复 (HRR).
- 使用贝叶斯信息标准 (BIC) 的混合效应线性回归模型来分析ANS测量的贡献.
主要成果:
- 平均心血管-关节PWV为7.12 m/s,平均心血管-辐射PWV为8.51 m/s.
- 平均静脉压下降为10.0%,表示静脉压从白天到晚上的百分比变化.
- 系统性浸泡显示出与动脉辐射PWV (MD -0.09 m/s) 的独立关联,这种关联产生了最低的BIC得分.
结论:
- 系统性浸泡与慢性脏病患者的动脉辐射PWV有关,这表明它可能作为ANS功能的替代标记物.
- 在缩浸泡和带-椎PWV之间没有发现显著的关联.
- 需要进一步的研究,以阐明ANS功能,动脉硬和慢性病患者心血管事件之间的长期相互作用.
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