甲状腺功能障碍异常性肺动脉高血压的临床特征和长期存活率:来自全国多中心前性研究的见解
Yuling Qian1, Ruilin Quan1, Xiaoxi Chen1
1Department of Pulmonary Vascular Disease, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital, Beijing, China.
患有临床甲状腺功能障碍的异常性肺动脉高血压 (IPAH) 患者表现出改善的血液动力学和生存率. 在IPAH患者中,亚临床甲状腺功能低下的结果与没有甲状腺问题的患者有相似的结果.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 肺部医学 肺部医学
背景情况:
- 异常性肺动脉高血压 (IPAH) 是一种罕见的疾病,具有显著的发病率和死亡率.
- 甲状腺功能障碍是一种常见的并发症,可能会影响IPAH特征和结果.
- 甲状腺状况与IPAH患者预后之间的关系需要进一步阐明.
研究的目的:
- 调查与同时存在的甲状腺功能障碍的IPAH患者的临床特征和长期存活率.
- 为了将这些结果与具有正常甲状腺功能 (euthyroid) 的IPAH患者进行比较.
主要方法:
- 对从IPAH患者收集的前性数据的回顾性分析.
- 在基线包括甲状腺功能障碍患者;排除其他肺高血压组.
- 根据年龄和性别,IPAH患者与甲状腺功能障碍患者的1:1匹配.
主要成果:
- 分析了148名患有甲状腺功能障碍的IPAH患者,包括甲状腺功能障碍症,甲状腺功能障碍症,亚临床甲状腺功能障碍症和亚临床甲状腺功能障碍症.
- 与无甲状腺 IPAH 患者相比,患有甲状腺功能过高和甲状腺功能低下的 IPAH 患者表现出明显较低的肺血管抵抗 (PVR).
- 临床甲状腺功能障碍 (高甲状腺和低甲状腺症) 的IPAH患者的长期存活率比没有甲状腺功能障碍的患者要好.
结论:
- 临床甲状腺功能障碍和甲状腺功能障碍与IPAH患者的血液动力学和生存率的改善有关.
- IPAH患者的亚临床甲状腺功能低下症显示出与没有甲状腺功能障碍的IPAH患者相似的血液动力学概况和生存率.
更多相关视频
06:08Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
07:29The Left Pneumonectomy Combined with Monocrotaline or Sugen as a Model of Pulmonary Hypertension in Rats
Published on: March 8, 2019
相关概念视频
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
