在102 792名成年人中,静脉血栓塞栓症与严重呼吸不良和喘相关
Kristin Felicia Nilausen1, Eskild Morten Landt1, Suzan Al-Shuweli1
1Department of Clinical Biochemistry, Zealand University Hospital, Køge, Denmark.
ERJ open research
|November 29, 2023
概括
患有静脉血栓塞栓症 (VTE) 的个人经历了肺功能减弱和呼吸障碍和喘风险增加. 在一般人群中,VTE对这些情况做出了重大贡献,突出了进一步研究和管理策略的需要.
科学领域:
- 肺部医学 肺部医学
- 心血管医学 心血管医学
- 遗传学 是一个遗传学.
背景情况:
- 肺栓塞 (PE) 准则承认长期的后果,如呼吸不全和慢性血栓栓塞性肺高血压.
- 然而,PE和静脉血栓塞栓症 (VTE) 对一般人群肺功能和喘风险的影响仍然被低估.
研究的目的:
- 调查静脉血栓塞栓症 (VTE),包括肺栓塞 (PE) 和深静脉血栓症 (DVT) 与肺功能之间的关联.
- 评估在有VTE病史的个人中呼吸障碍和喘的风险.
主要方法:
- 利用了哥本哈根一般人口研究中的102,792名成年人的数据.
- 从丹麦国家患者登记册中提取了VTE,PE,DVT和喘诊断.
- 对因子V莱登和前素G20210A基因变异进行了基因型定型.
主要成果:
- 患有VTE的个体表现出肺功能减弱 (92%预测FEV1vs96%对照组,p<0.001).
- VTE与轻度,中度和重度呼吸障碍的几率显著增加有关 (aORs 1.4-1.7).
- 在患有VTE (aOR1.6) 的人群中观察到喘风险较高,遗传变异也与喘风险有关.
结论:
- 静脉血栓塞栓症与肺功能受损以及严重呼吸不良和喘的风险增加有关.
- 在一般人群中,VTE占严重呼吸不良 (3.5%) 和喘 (3.0%) 病例的显著比例.
- 这些发现强调了VTE在急性事件之外的系统影响.
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