基于体重的理想体质的最低口服卡路里的确定有利于ALS的功能和生存
Ryutaro Nakamura1, Mika Kurihara2, Shuhei Kobashi1
1Department of Neurology, Shiga University of Medical Science, Otsu, Japan.
Frontiers in neurology
|November 29, 2023
概括
对于肌缩性侧面硬化症 (ALS) 患者来说,摄入至少25千卡/千克理想体重 (IBW) 与更好的结果有关. 热量摄入量显著影响ALS患者的生存和功能.
科学领域:
- 神经学 神经学
- 营养科学 营养科学
- 生物统计学 生物统计学
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病.
- 优化营养管理对于改善ALS患者的功能和生存至关重要.
研究的目的:
- 为了确定ALS患者的理想热量摄入量.
- 为了比较每人理想体重 (IBW) 的口服摄入量与总能耗 (TEE).
主要方法:
- 对104名ALS患者的回顾性分析.
- 根据热量摄入量进行分类:<25千卡/公斤IBW,25-30千卡/公斤IBW和>30千卡/公斤IBW.
- 使用石家庄公式评估口服和TEE之间的差异.
主要成果:
- 每个IBW的口服热量摄入与功能衰退速度较慢相关 (rs = -0.35,p < 0.001).
- 消耗≥30千卡/千克IBW的患者的中位生存时间最长 (63个月),其次是25-30千卡/千克IBW (38个月) 和<25千卡/千克IBW (24个月).
- 卡路里摄入量<25 kcal/kg IBW 是患者结果的显著负面预测因素,独立于其他因素.
结论:
- 口服热量摄入量为25 kcal/kg IBW或以上与ALS患者的改善结果有关.
- 建议进行进一步的大规模,多区域的研究来验证这些发现.
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