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面对面双关联网络和感觉运动网络的功能连接性改变与白发的行为异质性有关

Xiao-Feng Huang¹, Xin-Qing Hao¹, Xiao-Xue Yin¹

¹Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Frontiers in neurology

|November 29, 2023

概括

这项研究揭示了初级白发作 (BSP) 亚型中神经连接的明显差异. 这些发现可能有助于识别早期诊断的生物标志物,并为白发作 (BSP) 和眼开口 (AEO) 的失调提供个性化治疗.

科学领域:

神经科学是一个神经科学.
临床神经学临床神经学
医疗成像医学成像

背景情况:

初级白发作 (BSP) 呈现异质的临床特征,包括孤立的性眼关闭和眼打开 (AEO) 的无力.
了解这些BSP表型背后的独特神经机制对于有针对性的治疗策略至关重要.

研究的目的:

为了研究孤立的BSP和BSP相关的AEO亚型之间的神经机制的差异.
使用功能近红外光谱学 (fNIRS) 探索不同BSP表型的病理生理学.

主要方法:

横截面研究涉及29个孤立的BSP患者,17个BSP与AEO患者以及28个健康对照.
静止状态功能近红外光谱学 (fNIRS) 用于评估前端对面控制网络 (FPCN) 和传感运动网络 (SMN) 中的功能连接 (FC).
进行了改变FC和行为数据之间的相关性分析.

主要成果:

与隔离的BSP组相比,在AEO组的BSP中观察到左前运动皮层和上边脊椎之间FPCN的FC降低.
这两个BSP子组在SMN中表现出低连接性,特别是涉及左前运动皮质.
这种低连接性与毒素A治疗的累积数量呈正相关性,表明了运动控制的调制.

结论:

独特的神经连接性改变的特征是BSP的不同行为表型.
识别这些网络特异性的变化可能会导致早期诊断的潜在生物标志物.
这些发现可以指导个性化神经调节点治疗各种BSP亚现型.

关键词:

眼开口的疏松症眼的开口.这是一种白性动 (blepharospasm).前沿平行控制网络的控制网络.功能近红外光谱学近红外光谱学传感器运动网络的传感器.

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