在Ex Situ期间的器官修复和再生动态保存:未来是纳米
Nicholas Gilbo1,2, Joris Blondeel1,3, Jacques Pirenne1,3
1Laboratory of Abdominal Transplantation, Department of Microbiology, Immunology and Transplantation, Faculty of Medicine, KU Leuven, Leuven, Belgium.
概括
机器输液 (MP) 有助于器官选择,但受损的器官仍然被丢弃. 在MP期间使用介质细胞 (MSC) 秘密体或细胞外囊泡的策略显示出在移植前对ex situ器官修复和再生的希望.
科学领域:
- 再生医学是一种再生医学.
- 移植生物学 移植生物学
- 生物技术是生物技术.
背景情况:
- 机器输液 (MP) 允许对器官进行移植评估,但由于损伤,器官丢弃仍然存在,这凸显了对移植前修复策略的关键需求.
- 系统性介质瘤细胞 (MSC) 治疗在减少缺血-再输液损伤方面取得了临床前的成功,但在临床试验中由于输送效率低下而失败.
- 在MP期间探索了直接MSC的管理,但也受到亚最佳细胞递送和短细胞寿命的限制.
研究的目的:
- 审查和讨论使用机器输液的 ex situ 器官修复和再生的新策略.
- 评估MP期间介质细胞 stromal cell (MSC) 秘密和细胞外囊泡 (EV) 治疗的潜力,作为直接细胞给药的替代方案.
- 在机器输液的背景下,推测移植前器官修复和再生的未来.
主要方法:
- 关于机器 perfusion (MP) 器官保存和评估的当前文献的综述.
- 关于移植中中干细胞 (MSC) 治疗的临床前和临床研究的分析.
- 探索基于MP的MSC分泌体和细胞外囊泡 (EVs) 的传递,用于器官修复.
主要成果:
- 虽然在MP期间直接MSC管理面临交付挑战,但使用MSC秘密和/或EV显示在利用MSC属性方面更高效.
- MP 处于独特的位置,可以促进 ex situ 器官的修复和再生,解决器官丢弃所留下的差距.
- 初步发现表明,MP期间的MSC分泌/EV疗法是提高器官活力的有希望的方法.
结论:
- 在机器输液 (MP) 过程中,介质细胞 stromal cell (MSC) 秘密和细胞外囊泡 (EV) 疗法为 ex situ 器官修复提供了比直接细胞给药更有效的策略.
- 使用MP的ex situ器官修复和再生领域正在迅速发展,具有改善器官移植利用的巨大潜力.
- 未来的研究应该专注于优化MSC分泌/EV传递和MP环境中的治疗效果,以打击器官丢弃和改善移植结果.
关键词:
动态维护 维护 动态维护细胞外囊泡中的细胞外囊泡.机器 perfusion perfusion perfusion 透机是什么? 机器是什么? 机器是什么?介质细胞干细胞介质细胞干细胞器官的保存器官的保存器官再生器官的再生器官修复器官的修复器官的修复器官更多相关视频
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