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相关概念视频

Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
Bone Remodeling01:40

Bone Remodeling

38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

4.0K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
4.0K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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相关实验视频

Updated: Jul 9, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

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低骨矿物质密度与英国生物银行的灰质体积减少有关.

Polona Kalc1, Robert Dahnke1,2, Felix Hoffstaedter3,4

  • 1Structural Brain Mapping Group, Department of Neurology, Jena University Hospital, Jena, Germany.

Frontiers in aging neuroscience
|November 29, 2023
PubMed
概括
此摘要是机器生成的。

低骨矿物质密度 (BMD) 与老年妇女的灰质 (GM) 损失有关,特别是在受阿尔茨海默病 (AD) 影响的大脑区域. 这种关联在男性中不那么明显,即使在健康的个体中也是如此.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.英国生物银行这就是VBM的VBM.骨矿物质密度 骨矿物质密度骨质疏松症是一种骨质疏松症.

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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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相关实验视频

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Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
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科学领域:

  • 神经成像是一种神经成像.
  • 老年学是一门学科.
  • 骨健康 骨健康 骨健康

背景情况:

  • 之前的研究表明,在阿尔茨海默病 (AD) 中,低骨矿物质密度 (BMD) 和灰质 (GM) 体积减少之间存在联系.
  • 在健康老龄化人口中,BMD和GM体积之间的关系仍然不太清楚.

研究的目的:

  • 来自英国生物银行的大型健康老年人队列中研究BMD和GM体积之间的关联.
  • 为了确定BMD是否与大脑区域的GM体积变化相关,大脑区域通常会在AD早期受到影响.

主要方法:

  • 使用CAT12软件对T1加权核磁共振扫描进行了基于voxel的形态测量 (VBM) 分析.
  • 数据包括5518名65-82岁的女性和7595名男性,没有神经或精神疾病.
  • 无值集群增强 (TFCE) 用于全脑分析.

主要成果:

  • 在女性身上观察到显著的GM体积减少,包括上额,中和状回旋,以及海马和带带皮层.
  • 在男性中观察到较小的影响,主要发生在下区域,基底前脑和脑内皮层.
  • 这些女性受影响的区域与在AD早期受影响的区域重叠.

结论:

  • 骨髓损伤与老年女性的转基因体积减少有关,特别是在与阿尔茨海默病相关的大脑区域.
  • 在老年男性中,BMD和GM体积之间的关联不那么明显.
  • 这些发现表明,骨健康和老化中的大脑结构之间存在潜在的联系,即使没有神经退行性疾病.