低骨矿物质密度与英国生物银行的灰质体积减少有关
Polona Kalc1, Robert Dahnke1,2, Felix Hoffstaedter3,4
1Structural Brain Mapping Group, Department of Neurology, Jena University Hospital, Jena, Germany.
Frontiers in aging neuroscience
|November 29, 2023
概括
低骨矿物质密度 (BMD) 与老年妇女的灰质 (GM) 损失有关,特别是在受阿尔茨海默病 (AD) 影响的大脑区域. 这种关联在男性中不那么明显,即使在健康的个体中也是如此.
科学领域:
- 神经成像是一种神经成像.
- 老年学是一门学科.
- 骨健康 骨健康 骨健康
背景情况:
- 之前的研究表明,在阿尔茨海默病 (AD) 中,低骨矿物质密度 (BMD) 和灰质 (GM) 体积减少之间存在联系.
- 在健康老龄化人口中,BMD和GM体积之间的关系仍然不太清楚.
研究的目的:
- 来自英国生物银行的大型健康老年人队列中研究BMD和GM体积之间的关联.
- 为了确定BMD是否与大脑区域的GM体积变化相关,大脑区域通常会在AD早期受到影响.
主要方法:
- 使用CAT12软件对T1加权核磁共振扫描进行了基于voxel的形态测量 (VBM) 分析.
- 数据包括5518名65-82岁的女性和7595名男性,没有神经或精神疾病.
- 无值集群增强 (TFCE) 用于全脑分析.
主要成果:
- 在女性身上观察到显著的GM体积减少,包括上额,中和状回旋,以及海马和带带皮层.
- 在男性中观察到较小的影响,主要发生在下区域,基底前脑和脑内皮层.
- 这些女性受影响的区域与在AD早期受影响的区域重叠.
结论:
- 骨髓损伤与老年女性的转基因体积减少有关,特别是在与阿尔茨海默病相关的大脑区域.
- 在老年男性中,BMD和GM体积之间的关联不那么明显.
- 这些发现表明,骨健康和老化中的大脑结构之间存在潜在的联系,即使没有神经退行性疾病.
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