风险因素,临床特征和脑内出血结果的年龄相关差异
Chu Chen1, Yanfang Xie2, Mingjun Pu1
1Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in aging neuroscience
|November 29, 2023
概括
年轻成年人的脑内出血 (ICH) 与老年患者不同,白细胞数量和BMI较高. 年轻的ICH患者经历了更有利的功能结果,尽管类似的短期死亡率.
科学领域:
- 神经学 神经学
- 脑卒中研究 脑卒中研究
- 流行病学 流行病学
背景情况:
- 脑内出血 (ICH) 是一种严重的中风类型,特别是在年轻人中缺乏研究.
- 了解年轻ICH患者的风险因素和临床表现对于有针对性的干预至关重要.
研究的目的:
- 调查年轻成年人脑内出血的临床表现和危险因素.
- 将这些因素和结果与老年ICH患者的结果进行比较.
主要方法:
- 一项针对1003名ICH患者的前性队列研究 (2016年3月 - 2021年12月).
- 年轻 (≤50岁) 和老年 (>50岁) ICH患者之间的人口统计数据,病因,风险因素和临床结果的比较.
- 后勤回归分析以确定3个月功能独立和结果的预测因素.
主要成果:
- 年轻ICH患者的二次ICH比例较高,白细胞数量增加,体重指数 (BMI) 较高,与老年人相比,糖尿病较少.
- 三个月功能独立的预测因素包括首次ICH和年龄≤50岁.
- 病/中风病史,较高的NIHSS得分,较大的血瘤体积和水头与糟糕的结果有关. 白细胞计数显著影响了年轻ICH患者的预后.
结论:
- 脑内出血 (ICH) 发生率在50-69岁年龄组达到顶峰,但年轻人呈现出明显的特征 (较高的WBC,BMI) 和病因分布.
- 年轻的ICH患者表现出类似的短期死亡率,但与老年人相比,3个月的功能结果更有利.
- NIHSS评分和血瘤体积是所有年龄组不良结果的关键指标.
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