维生素D和孕前:一个系统的审查和元分析
Abdulla AlSubai1, Muhammad Hadi Baqai2, Hifza Agha3
1Royal College of Surgeons in Ireland, Dublin, Ireland.
SAGE open medicine
|November 29, 2023
概括
低维生素D水平增加了孕前的风险,而补充剂显著降低了它. 这项研究强调了维生素D.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 孕产妇健康 孕产妇健康
背景情况:
- 孕前是一种常见的妊娠障碍,在全球范围内影响2%-8%.
- 关于25-基维生素D缺乏和孕前风险之间的关联存在相互矛盾的研究.
- 了解这种关系对于孕产妇健康干预至关重要.
研究的目的:
- 为了评估母亲的25-基维生素D水平与孕前风险之间的关系.
- 评估25-基维生素D补充剂对孕前发病率的影响.
- 探索25-基维生素D作为孕前的潜在预防策略.
主要方法:
- 在Medline数据库上进行了全面的文献搜索,截至2021年7月.
- 包括随机对照试验和观察性研究,检查25-氧维生素D和孕前.
- 结果使用随机效应元分析与曼特尔-汉泽尔赔率比率进行了合成.
主要成果:
- 对34项研究的分析 (10项RCT,24项观察性) 揭示了重要的发现.
- 缺乏25-基维生素D与妊娠前风险增加密切相关 (ORs从1.61到4.30不等).
- 补充25-基维生素D显著降低了孕前的发生率 (OR:0.50;p=0.00001).
结论:
- 低的母体25-氧维生素D度与更高的孕前的风险有关.
- 服用25-基维生素D补充剂显示出对孕前有显著的保护作用.
- 补充维生素D可以作为一种可行的干预措施,以减少妊娠前的发生率并改善母亲的结果.
关键词:
25 (((OH) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D)这种高血压,高血压.发生率的发生率.这是一个元分析.孕前症是什么意思怀孕 怀孕 怀孕 怀孕 怀孕治疗治疗治疗治疗治疗治疗维生素D是维生素D的重要组成部分.更多相关视频
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