重新审视阿梅洛布拉斯;在口腔生物学之外,解决EMT-ECM轴
Janne E Reseland1,2, Catherine A Heyward2, Athina Samara1,2
1Center for Functional Tissue Reconstruction (FUTURE), University of Oslo, Oslo, Norway.
Frontiers in cell and developmental biology
|November 29, 2023
概括
牙面膜所知的阿米洛布拉斯 (AMBN) 是新发现的在胃肠道. 这表明AMBN在肠道组织完整性和潜在的上皮层-介质细胞过渡 (EMT) 中发挥作用.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 胃肠病学 胃肠病学
背景情况:
- 氨基母细胞蛋白 (AMBN) 主要被认可为其在牙质形成中的功能,包括细胞分化,矿化和细胞矩阵粘附.
- 在各种非牙科组织中也发现了AMBN,例如骨,血液和脂肪组织,以及介质干细胞.
研究的目的:
- 为了研究在胃肠道中Ameloblastin (AMBN) 的表达和潜在功能.
- 探索AMBN,细胞外矩阵 (ECM) 完整性和上皮-介质细胞过渡 (EMT) 之间的关联,超出其在口腔生物学中的已知作用.
主要方法:
- 免疫光被用来检测在消化道的不同区域的AMBN表达.
- 在各种胃肠道组织中分析AMBN mRNA和蛋白质水平.
主要成果:
- 在GI通道的多个段落中确定了AMBN表达.
- 检测到AMBN mRNA和蛋白质表明它在GI细胞外基质 (ECM) 的结构和组织完整性中发挥了作用.
- 在特定细胞子集中的细胞内AMBN表达表明在信号通路和上皮层-介质细胞过渡 (EMT) 中的潜在作用.
结论:
- 氨基母细胞蛋白 (AMBN) 的表达范围超出牙组织,在肠道中显著存在.
- AMBN可能有助于胃肠道ECM的结构完整性,并与EMT法规有关.
- 这项研究提出AMBN作为一个潜在的关键调节器,将GI系统中的ECM动态和EMT联系起来,为其生物功能提供了新的视角.
相关概念视频
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
Metastasis
5.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.6K
The Extracellular Matrix
9.0K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
9.0K
Cadherins in Tissue Organization
3.0K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.0K
Basal Lamina are the Specialized Form of ECM
2.8K
The basal lamina is a thin extracellular layer that lies underneath the cells and separates them from other tissues. The three layers of the basal lamina are lamina lucida, lamina densa and lamina reticularis. The basal lamina, a mixture of glycoproteins and collagen, provides an attachment site for the epithelium, separating it from underlying connective tissue. The framework of basal lamina has other essential proteins such as laminins mesh, perlecan, entactin, and type IV collagen.
Proteins...
Proteins...
2.8K
Cell Motility through Blebbing
1.9K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Blebbing Through the Matrix
In multicellular...
1.9K


