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身体活动与腰部疼痛,椎间盘退化和脑脊髓炎的因果关系:一项两样本的孟德尔随机化分析研究

Xiaoqing Guan¹, Ding Zhang¹, Fengyi Zhang¹

¹Departments of Orthopedics Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Frontiers in cell and developmental biology

|November 29, 2023

概括

身体活动 (PA) 与腰部疼痛 (LBP) 有因果关系,平均加速降低了LBP风险,高加速增加了LBP风险. 对于椎间盘退化或坐骨髓炎,没有发现因果关系.

科学领域:

流行病学流行病学
遗传学是一个遗传学.
整形外科整形外科整形外科

背景情况:

之前的研究还没有明确地确定身体活动 (PA) 和腰部疼痛 (LBP),椎间盘退化 (IDD) 或坐骨神经炎之间的因果关系.
门德尔随机化 (MR) 提供了一种强大的方法来研究使用遗传变异作为仪器变量来研究潜在的因果关系.

研究的目的:

确定各种体育活动表型与患下背部疼痛,椎间盘退化和坐骨神经炎的风险之间的因果关系.
利用双样本的门德尔随机化方法来分析现有的全基因组关联研究数据,用于暴露和结果表型.

主要方法:

选择了四种体力活动表型:基于加速度计 (平均加速度,加速度分数>425毫克) 和自我报告 (中度至剧烈,剧烈).
使用严格的标准 (p < 5 × 10−8,LD r2 < 0.01,等等) 确定了与身体活动相关的单核酸多态 (SNP). ) 的情况.
在因果推断和灵敏度分析中采用逆方差加权 (IVW),MR-Egger和加权中位数方法,不包括混SNP.

主要成果:

门德尔的随机分析揭示了身体活动和腰部疼痛之间的因果关系.
基于加速度计的PA与更高的加速度分数 (>425毫克) 显示出与LBP的积极因果关系 (OR:1.818).
基于加速度计的PA与平均加速显示了与LBP (OR:0.945) 的负因果关联,这表明它具有保护作用.

结论:

增加平均体力活动,同时避免高强度活动,可能是预防腰部疼痛的策略.
身体活动似乎与椎间盘退化或脑脊髓炎没有直接的因果关系.
这些发现表明,身体活动通过间接途径而不是直接因果关系影响磁盘退化和 sciatica.

关键词:

椎间盘退化椎间盘退化腰部疼痛腰部疼痛腰部疼痛门德尔的随机化是门德尔的随机化身体活动身体活动这是一种坐骨神经炎.

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