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一个系统的免疫和预后分析CD48与瘤微环境的相互作用在泛癌症

Mingdong He¹, Jun Yu¹, Shaohua Chen²

¹Department of Urology, the First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.

International journal of general medicine

|November 29, 2023

概括

分化集群48 (CD48) 影响泛癌预后和免疫透. 评估CD48可能会改善患者的治疗结果和免疫治疗反应预测.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

CD48是一种信号淋巴细胞激活分子家族成员,在造血细胞上表达.
它在癌预后和免疫透中的作用需要进一步澄清.

研究的目的:

研究CD48对胰腺癌预后和免疫透的影响.
评估CD48作为患者结果和免疫治疗反应的潜在生物标志物.

主要方法:

对TCGA,TIMER和TIDE数据库进行CD48表达的系统分析.
与瘤突变负担 (TMB),微卫星不稳定性 (MSI),瘤微环境 (TME) 和免疫基因的相关性分析.
生物信息工具 (ESTIMATE,GSEA) 和通过qPCR和西式涂抹进行验证.

主要成果:

与正常组织相比,CD48表达在胰癌中显著改变.
CD48与整体存活率 (OS),无病区间 (DFI),无进展区间 (PFI) 和疾病特异性存活率 (DSS) 相相关.
CD48与TMB,MSI,免疫细胞透和TME中的 stromal组件有关.

结论:

CD48是胰腺癌的一个重要预后因素.
CD48可以作为一个有价值的生物标志物来预测患者的预后和免疫治疗反应.

关键词:

CD48 CD48 CD48 CD48 CD48 CD48 CD48 CD48 CD48 CD48 CD48 CD48 CD48 CD48 免疫疗法免疫疗法胰腺癌是一种癌症.瘤微环境是一个微环境.

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