在卡塔尔,CT值与COVID-19严重程度和死亡率之间没有关联
Khaleed Jemmieh1, Mohamed Tawengi1, Tamader Alyaarabi1
1Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar.
反映SARS-CoV-2病毒载量的周期值 (Ct) 值没有预测COVID-19的严重程度或死亡率. 然而,呼吸道和胃肠道症状与加大卡塔尔的ICU入院和死亡风险有关.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 循环值 (Ct) 值表示的SARS-CoV-2病毒载荷与COVID-19严重程度之间的关系尚不清楚.
- 了解这种关联对于预测患者的结果和管理医疗保健资源至关重要.
研究的目的:
- 调查SARS-CoV-2周期值 (Ct) 值与COVID-19严重程度之间的关联,包括重症监护室 (ICU) 的入院和死亡率.
- 确定特定症状在预测严重疾病和死亡中的作用.
主要方法:
- 在卡塔尔进行了一项病例控制研究,涉及2020年3月至9月住院的COVID-19患者.
- 用多变量回归模型对Ct值进行了分类分析 (低于和高于25),并与报告的症状一起评估它们与ICU入院和死亡率的关联.
主要成果:
- 在Ct值 (分类为<25对≥25) 和ICU入院或死亡的几率之间没有发现显著的关联.
- 呼吸系统症状 (OR 2.95用于ICU入院,OR 4.96用于死亡率) 和胃肠道症状 (OR 1.99用于ICU入院,OR 3.17用于死亡率) 与ICU入院和死亡的更高几率显著相关.
结论:
- 对于COVID-19的严重程度,RT-PCR Ct值显示出有限的预后值.
- 呼吸道和胃肠道症状是COVID-19患者严重疾病和死亡率的重要预测因素.
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