向转化生长因子β信号转移在转移性骨髓肉瘤中的目标
1Hillman Cancer Center at Central Pennsylvania, University of Pittsburg Medical Center, Harrisburg, PA, 17109, USA.
Journal of bone oncology
|November 29, 2023
概括
转化生长因子β (TGF-β) 信号促进骨髓瘤的进展和转移. TGF-β对手在治疗这种罕见的骨癌方面表现有前途,在临床试验中使用了一些药物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 骨髓瘤是一种罕见的骨癌,主要影响年轻人,转移性疾病的结果不佳.
- 转化生长因子β (TGF-β) 信号在癌症中具有复杂的作用,在早期的上皮癌中起到瘤抑制作用,但在晚期的癌症中起到促进作用.
- 在骨髓瘤等介质瘤中,TGF-β信号似乎主要促进瘤生长和转移.
研究的目的:
- 审查TGF-β信号传递在骨髓瘤发病过程中的作用.
- 讨论TGF-β信号抗剂在骨髓瘤治疗中的开发和治疗潜力.
主要方法:
- 对TGF-β信号在骨髓瘤中的现有文献的综述.
- 各种TGF-β抗剂药物开发策略的总结.
- 对TGF-β抗剂在骨髓瘤和其他疾病中的临床试验数据的概述.
主要成果:
- TGF-β信号传递与促进骨髓瘤生长,上皮细胞-介质细胞转换 (EMT),免疫逃避,纤维化和血管生成有关.
- 已经开发出几种类型的TGF-β对抗剂,包括抗体,配体陷,反感核酸和小分子抑制剂.
- 临床前研究表明,TGF-β抗体可以抑制骨髓瘤的生长和转移;临床试验正在评估它们的安全性和有效性,其中一些表明有希望.
结论:
- 准TGF-β信号传递是一种有前途的骨髓瘤治疗策略.
- 目前正在进行的临床试验,例如Vactosertib的临床试验,将进一步阐明TGF-β抗剂在骨髓瘤中的有效性.
- 卢斯帕特塞普特 (Luspatercept) 作为TGF-β抗剂的安全性概况通常是可以接受的,这支持它们的持续调查.
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