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在尼日利亚南部的麻风患者中评估血液学参数

Inyeneobong Ernest Inyang¹, Iya Eze Bassey², Henshaw Uchechi Okoroiwu³

¹B.MLS, Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, PMB 1115, Cross River State, Nigeria.

|November 29, 2023

概括

这项研究发现了麻风患者的高贫血率,并确定了绝对乙氨基酸计数作为麻风反应的潜在生物标志物. 这些发现表明,改善治疗后管理和早期反应检测至关重要.

科学领域:

传染性疾病传染性疾病
血液学血液学血液学
免疫学免疫学免疫学

背景情况:

麻风病是由*Mycobacterium leprae*引起的,是一种慢性传染病,主要影响皮肤,周围神经系统和上呼吸道粘膜.
麻风患者的免疫反应很常见,因此需要识别预测生物标志物以进行早期干预.

研究的目的:

为了评估麻风患者的血液学参数.
为了确定病反应发生的潜在生物标志物.

主要方法:

一项涉及60名麻风患者 (在多药疗法和治疗后) 和30名健康对照者的横截面研究.
使用Sysmex KX-21N自动分析仪进行血液学分析.
统计分析包括ANOVA,Kruskal Wallis,ROC曲线分析和双变量后勤回归.

主要成果:

与对照组相比,麻风患者的红细胞计数,血红蛋白和血红素显著减少.
在麻风患者中观察到白细胞数量升高,绝对淋巴细胞,中性细胞,单细胞和氨酸细胞数量升高.
65%的麻风患者患有贫血. 绝对的乙氨基基酸计数显示了作为麻风反应发病的生物标志物的潜力 (AUC 0.709).
性别和绝对乙氨基酸细胞计数与麻风反应有关.

结论:

由于贫血的高频率,因此需要加强麻风患者治疗后的治疗策略.
绝对乙酸细胞计数被确定为预测麻风反应发病的潜在生物标志物.

关键词:

这是大麻风病.它具有诊断价值的诊断价值.麻风病的反应反应预测价值是一个预测值.

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