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精神分裂症谱系障碍中的光学一致性断层扫描:系统性审查和元分析

William Shew¹, Daniel J Zhang², David B Menkes³

¹Department of Ophthalmology, New Zealand National Eye Centre, University of Auckland, Auckland, New Zealand.

Biological psychiatry global open science

|November 29, 2023

概括

精神分裂症谱系障碍 (SSD) 与内视网膜缩有关,由福里埃域光学连贯断层扫描 (OCT) 扫描证实. 这项系统性审查发现SSD患者视网膜显著变薄,这表明它有可能作为生物标志物.

科学领域:

眼科医生眼科眼科
神经科学是一个神经科学.
精神病学是一个精神病学.

背景情况:

内视网膜缩越来越多地被认为是精神分裂症谱系障碍 (SSD).
光学连贯断层扫描 (OCT) 是可视化视网膜结构的关键技术.
富里埃域OCT设备为SSD研究提供了先进的成像功能.

研究的目的:

系统地审查和分析使用福里埃域OCT的研究,以评估SSD中的视网膜变化.
与对照人群相比,量化SSD患者内视网膜缩的程度.

主要方法:

在2022年5月之前进行全面的数据库搜索 (MEDLINE,PubMed,Scopus,Embase,PsycInfo,PYSNDEX,WHO,Cochrane)
包括经过同行评审的成人SSD病例控制研究,使用Fourier域OCT.
排除了眼部病理和独立数据评估和提取的研究.

主要成果:

36项研究符合审查标准;24项 (1074例,854例对照) 被纳入分析.
在SSD组,总体上呈现出显著较薄的外皮皮质视网膜神经纤维层 (-3.26微米) 和黄斑层 (-7.88微米).
在SSD中也观察到更薄的斑点性结节细胞内状亚层 (-2.44μm),在所有分析中一致.

结论:

患有SSD的个体表现出普遍的视网膜缩,可能反映出大脑体积减少.
视网膜缩可能作为SSD的生物标志物.
需要进一步的纵向研究来控制混因子,以验证视网膜缩作为SSD生物标志物.

关键词:

进行元分析分析.光学连贯性断层扫描仪精神分裂症是一种精神分裂症.精神分裂症谱系障碍精神分裂症谱系障碍系统性审查系统性审查

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