全血细胞计数衍生的炎症生物标志物与牛皮和死亡率的关联
Yang Zhao1,2, Xu Tong Yang1, Yan Ping Bai3
1Department of Dermatology, Daxing Teaching Hospital, Capital Medical University, Beijing, 102600, People's Republic of China.
Clinical, cosmetic and investigational dermatology
|November 29, 2023
概括
全血细胞计数衍生的炎症标志物,如中性粒细胞与淋巴细胞比率 (NLR),与牛皮的患病率有关. 一些标记物,包括中性粒细胞与单细胞与淋巴细胞比率 (NMLR),预测牛皮患者的全因死亡率.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 牛皮是一种慢性炎症性疾病,影响3%的人口.
- 牛皮与心血管疾病的风险增加有关.
- 来自全血细胞计数 (CBC) 的炎症生物标志物可以提供有关疾病机制的见解.
研究的目的:
- 调查CBC衍生的炎症生物标志物与牛皮患病率之间的关联.
- 检查这些生物标志物与牛皮患者全因死亡率之间的相关性.
主要方法:
- 利用了2003-2014年国家健康和营养检查调查 (NHANES) 和国家死亡指数的数据.
- 分析CBC衍生的炎症标志物:中性细胞/淋巴细胞比率 (NLR),dNLR,单细胞数/淋巴细胞比率 (MLR), (中性细胞+单细胞) /淋巴细胞比率 (NMLR),血小板/淋巴细胞比率 (PLR) 和全身炎症反应指数 (SIRI).
- 采用加权后勤和考克斯回归分析,以及随机生存森林用于预后价值评估.
主要成果:
- 包括21,431名参与者;2.80%患有牛皮. 在8.83年的中位数随访期间发生了79例死亡.
- NLR,dNLR,NMLR,PLR和SIRI与牛皮的患病率有关.
- 在牛皮患者中,MLR,NMLR和SIRI与全因死亡率相关,NMLR是最强的预测因素.
结论:
- 来自CBC的炎症生物标志物与牛皮的患病率有关.
- 牛皮患者的全因死亡率与NMLR,SIRI和MLR有关.
- 这些CBC衍生指标可以作为高风险牛皮患者的简单查工具.
更多相关视频
06:29Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
Published on: March 1, 2011
26.4K
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
464
相关概念视频
01:38Inflammation
53.6K
Overview
53.6K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
96
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
96
01:24T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K