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血管锁定和锁定综合征:一个回顾性的案例系列
Laura Schnetzer1,2,3,4, Jürgen Steinbacher5, Gerhard Bauer6
1Department of Neurology, Neurological Intensive Care and Neurorehabilitation, Christian Doppler Medical Centre, Paracelsus Medical University, Ignaz-Harrer-Straße 79, Salzburg A-5020, Austria.
Therapeutic advances in neurological disorders
|November 29, 2023
概括
锁定综合症 (LiS) 涉及肌肉麻与保存的认知. 锁定加症综合征 (LiPS) 也影响了意识. 与LiS不同的是,LiPS病变超出了小马的范围.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 临床神经科学 临床神经科学
背景情况:
- 锁定综合症 (LiS) 的特点是,尽管存在严重的运动障碍,但仍能保持认知能力,这通常是由于腹部关节病变造成的.
- 一部分患者被称为锁定加症综合征 (LiPS),表现出额外严重的意识损伤.
- 区分LiS和LiPS对于适当的患者护理和管理至关重要.
研究的目的:
- 研究与血管相关的LiS和LiPS之间的结构差异,特别是病变模式和位置.
- 加强临床谱的划分,包括LiS和LiPS.
- 为了识别区分LiS和LiPS的放射性标记.
主要方法:
- 在2007年至2021年期间,对9名被诊断患有LiS或LiPS的患者进行了回顾性病例系列分析.
- 详细审查临床参数和MRI发现,包括由高级神经放射学家精确识别损伤结构.
- 病变的定量形状特征计算.
主要成果:
- 李斯病变是圆形的,仅限于小马.
- LiPS病变更长,延伸到相邻的区域,如大脑中,大脑下丘脑和上升的网状激活系统 (ARAS).
- 中大脑和丘脑的参与强烈表明了LiPS;对于pons-restricted病变,背部延伸和ARAS损伤,LiS与LiPS有区别.
结论:
- 损伤位置和形态是LiS和LiPS之间的关键差异.
- 中大脑和丘脑的参与表明LiPS,而形病变需要评估背部延伸和ARAS完整性.
- 精确的放射差异化至关重要,以防止LiPS被误诊为不响应的清醒综合征,并确保适当的治疗策略.
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