沙特阿拉伯成年人中COVID-19疫苗接种后感染:一个跨部门研究
Rehab A Mohammed1,2, Omar Baqais2, Samaher G Basalib2
1Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGY.
Cureus
|November 29, 2023
概括
尽管接种了疫苗,但COVID-19突破性感染可能会发生,但疫苗,特别是瑞疫苗,有效地减少了症状的严重程度. 糖尿病等并发症会增加感染风险,强调需要持续保持警.
科学领域:
- * 流行病学 流行病学
- * 疫苗学 疫苗学 疫苗学
- * 传染病 传染病
背景情况:
- *COVID-19疫苗是关键的流行病控制工具,但突破性感染仍然是一个问题.
- *了解疫苗对抗SARS-CoV-2感染的有效性和确定风险因素至关重要.
研究的目的:
- *评估瑞和阿斯特拉泽内卡COVID-19疫苗在预防突破性感染方面的有效性.
- * 确定与疫苗接种后COVID-19相关的风险因素和结果.
- *为了比较感染者在接种疫苗之前和接种疫苗后的症状严重程度.
主要方法:
- * 采用694名沙特成年居民自报数据的横截面研究,他们至少接种了两剂疫苗.
- *根据感染时间分类的参与者:疫苗接种前,疫苗接种后或两者兼而有之.
- *PCR确认的COVID-19病例分析了疫苗类型,并发病症和症状严重程度.
主要成果:
- * 17.8%的参与者在接种疫苗后感染了COVID-19,其中19.7%的参与者经历了突破性感染.
- * 瑞疫苗在未感染群体中显示出更高的患病率;在感染群体中显示出阿斯特拉泽内卡疫苗 (p<0.039).
- * 糖尿病显著增加了感染风险 (OR=2.29,p=0.001),尽管接种疫苗的人在感染后报告了不那么严重的症状.
结论:
- *虽然突破性感染是可能的,但COVID-19疫苗显著降低了症状严重程度.
- *与阿斯特拉泽内卡相比,瑞疫苗在预防感染方面表现出更大的有效性.
- *伴随性疾病,特别是糖尿病,与接种疫苗后COVID-19感染风险增加有关.
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