具有多个附体抗体的慢性突发性胎盘:产科医生的挑战
Girija S Mohanty1, Tanvi Katoch1, Sujata Siwatch1
1Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.
Cureus
|November 29, 2023
概括
管理Rh阴性女性的突发性胎盘,并进行免疫接种,这给诊断带来了挑战. 这个案例详细介绍了一种独特的慢性胎盘断裂与子宫内胎儿死亡,强调Rh阴性怀孕的复杂免疫血液学工作.
科学领域:
- 产科和妇科 产科和妇科
- 免疫血液学 免疫血液学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 胎盘断裂,或胎盘断裂,在怀孕期间存在重大风险.
- 孕妇的Rh阴性血型可能导致与免疫接种,特别是暴露于胎儿血液.
- 慢性胎盘断裂可能潜伏地出现,使诊断和管理复杂化.
研究的目的:
- 要突出O rhesus负血型和多种alloantibodies的primigravida中异形胎盘的复杂管理.
- 讨论慢性胎盘断裂的诊断挑战,包括ABO差异和Rh合免疫,在慢性胎盘断裂.
- 强调在怀疑慢性流产的阴性Rh怀孕中进行彻底的免疫血液学检查的重要性.
主要方法:
- 一个年轻的初怀孕的病例报告,呈现出子宫内血瘤和子宫内胎儿死亡.
- 血液组测试的详细分析,包括Rh (Rhesus) 和alloantibody查.
- 在免疫接种的背景下,对慢性胎盘断裂的管理策略的审查.
主要成果:
- 该患者是O rhesus阴性,对D,C和S抗原进行了同免疫接种.
- 慢性胎盘断裂的诊断因子宫内胎儿死亡和血液瘤而复杂化.
- 管理包括解决ABO差异,Rh合免疫和产后出血.
结论:
- 慢性胎盘断裂需要警的诊断和管理,特别是在具有 alloantibodies 的 Rh 阴性女性中.
- 综合性免疫血液学评估对于识别和管理与Rh合免疫接种相关的风险至关重要.
- 在Rh阴性怀孕中复杂的胎盘断裂病例中,建议早期和专业的输血医学咨询.
相关概念视频
01:22Development of Immunocompetence
315
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
315
01:15Transcytosis of IgG
2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K
01:19Rh Blood Group
1.5K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.5K
02:45Blood Transfusion and Agglutination
10.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.8K
01:10Blood Typing
1.2K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
1.2K
01:26Antibody Actions
1.1K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.1K