怀孕和炎症性风湿病:一个单一中心的回顾性队列研究
Abeer A Alkhodier1, Abdurhman S Alsaif2, Norah H Alqntash3
1College of Medicine, King Khalid University Hospital, King Saud University, Riyadh, SAU.
Cureus
|November 29, 2023
概括
患有类风湿性关节炎和狼等类风湿性疾病的妇女的怀孕结果在密切的多学科护理下是有利的. 生产性心脏阻塞是母亲抗SSA抗体阳性的风险.
科学领域:
- 类风湿病学 类风湿病学
- 产科 产科 产科 产科 产科
- 周围生理学 周围生理学
背景情况:
- 风湿性疾病在怀孕期间存在重大风险,包括早产,先天性心脏阻塞和流产.
- 这些情况在怀孕和产后可能会恶化,增加患者,胎儿和医疗保健系统的负担.
- 诊断和治疗方面的进步改善了结果,但需要密切的多学科跟踪.
研究的目的:
- 为了研究患有类风湿病的妇女怀孕后果.
- 了解这些疾病在怀孕期间的行为.
- 为了比较Sjogren综合征 (SS),全身性红斑狼 (SLE) 和类风湿性关节炎 (RA) 的结果.
主要方法:
- 沙特阿拉伯利雅得国王阿卜杜拉齐兹医疗城 (2016-2021) 的回顾性队列研究.
- 包括107名患有RA,SLE或初级SS的妇女的128例怀孕.
- 评估母亲健康,胎儿健康和妊娠并发症,包括疾病活动,药物,早产,先天性心脏阻塞和新生儿狼.
主要成果:
- 大多数怀孕 (95.58%) 发生在临床缓解的患者身上.
- 风湿病发作发生在7.87%的怀孕中.
- 有122例活产,20.16%为早产,13.22%需要NICU护理.
- 出生性心脏阻塞 (CHB) 发生在12.2%的新生儿出生于抗SSA阳性母亲.
- 五名新生儿被诊断出患有新生儿狼.
结论:
- 对于患有风湿病的妇女来说,怀孕的结果通常是有利的.
- 多学科的团队方法和密切的临床跟踪对于成功的结果至关重要.
- 低剂量普得尼索隆 (≤5毫克) 对母亲和胎儿的健康是安全的.
- 出生性心脏阻塞 (CHB) 是怀孕妇女具有阳性抗SSA抗体的一个重要问题.
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