南非黑人患有类风湿性关节炎的骨质疏松症
Tania Naidoo1, Lai-Ling Winchow2, Mohammed Tikly2
1Department of Internal Medicine, University of the Witwatersrand, Johannesburg, ZAF.
Cureus
|November 29, 2023
概括
功能状况较差的风湿性关节炎患者面临更高的骨质疏松症风险. 三重疗法在这个人群中显示出对骨质疏松症的保护作用,强调了早期查和干预的必要性.
科学领域:
- 类风湿病学 类风湿病学
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 骨质疏松症是类风湿性关节炎 (RA) 患者经常出现的并发症.
- 识别RA骨质疏松症的危险因素对于有效管理至关重要.
- 南非的RA黑人患者代表了本研究的特定人群.
研究的目的:
- 为了确定风险因素和骨质疏松症的预测因素,在患有类风湿性关节炎的黑人患者.
- 为了比较患有骨质疏松症和没有骨质疏松症的RA患者之间的人口统计,疾病活性和治疗特征.
主要方法:
- 对120名RA患者的回顾性研究 (60名患有骨质疏松症,60名没有).
- 收集的数据包括人口统计,疾病活性 (DAS-28 ESR),美国风湿病学会 (ACR) 功能状态和治疗方案.
- 双能X射线吸收计 (DEXA) 用于骨质疏松症评估. 统计分析包括t测试,奇平方测试和多变量逻辑回归.
主要成果:
- 一个较差的ACR功能类与骨质疏松症有显著的关联 (p = 0.03).
- 用三重疗法治疗的患者显示骨质疏松症的患病率明显降低 (35%vs63.3%,p=0.00).
- 该队列主要是女性 (95.5%),绝经后 (97.4%),平均年龄为67岁.
结论:
- 更糟糕的美国风湿病学学院功能类是黑人RA患者骨质疏松症的重要预测因素.
- 在这个队列中,使用三重疗法似乎对骨质疏松症有保护作用.
- 迅速识别风险因素,查和预防措施对于管理RA骨质疏松症至关重要.
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