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五因素修改脆弱指数作为对帕金森病深脑刺激手术结果的预测指标

Joshua U Hancock¹, Alexis L Price¹, Peter G Zaki²

¹Neurosurgery, Drexel University College of Medicine, Wyomissing, USA.

|November 29, 2023

概括

通过修改后的脆弱性指数-5 (mFI-5) 测量的脆弱性,预测了在接受深度大脑刺激 (DBS) 的帕金森病患者的并发症. 较高的脆弱性得分与增加的再入院和整体并发症相关,有助于预测手术结果.

科学领域:

神经外科神经外科
老年学是一门学科.
公共卫生公共卫生

背景情况:

帕金森病 (PD) 是一种流行的神经退行性疾病.
深度大脑刺激 (DBS) 是PD的有效手术治疗方法.
虚弱,这是减少生理储备的衡量标准,是外科手术结果的新兴预测因素.

研究的目的:

评估修改后的脆弱指数-5 (mFI-5) 作为PD患者进行DBS手术后并发症的预测指标.
评估脆弱程度和不良外科手术结果之间的关系.

主要方法:

使用了美国外科医生学院国家外科质量改进计划数据库 (2010-2019).
包括接受DPS治疗PD的患者,并使用mFI-5进行评分.
将患者分层分为没有脆弱性 (mFI-5=0),中度脆弱性 (mFI-5=1) 和显著脆弱性 (mFI-5≥2) 的组.

主要成果:

分析了1645名受试者,根据脆弱性分类他们:没有脆弱性 (N=877),中度脆弱性 (N=561),显著脆弱性 (N=207).
与没有虚弱相比,显著的虚弱与增加的无计划再入院 (OR 3.723),任何再入院 (OR 2.396),非家庭出院 (OR 4.317),和总体并发症 (OR 2.211) 相关.
中等脆弱性也显示了增加的无计划再接收 (OR 2.613).

结论:

mFI-5有效地预测了经过DBS的PD患者的术后并发症.
脆弱性评估可以帮助临床医生预测结果,并计划为脆弱患者提供术后护理.
这项研究强调了在PD的功能神经外科手术中脆弱性评估的重要性.

关键词:

深度大脑刺激 (DBS) 的方法脆弱脆弱脆弱脆弱脆弱修改过的脆弱指数-5 (mfi-5)运动障碍运动障碍帕金森病 (PD) 是一种在术后的结果.

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