高活性抗逆转录病毒疗法患者的眼部并发症:一个病例报告
Shovna Dash1, Soumya Kanta Mohanty1, Gayatree Mohanty1
1Ophthalmology, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Cureus
|November 29, 2023
概括
高活性抗逆转录病毒疗法 (HAART) 可能导致严重的眼部不良反应,包括免疫恢复性脑膜炎和肉结膜炎. 及时干预至关重要,斯蒂文斯-约翰逊综合征的病例证明了这一点.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 高活性抗逆转录病毒疗法 (HAART) 对于治疗艾滋病至关重要.
- 与HAART相关的眼部不良影响没有得到广泛报道.
- 了解这些影响对于患者管理和视觉健康至关重要.
研究的目的:
- 报告和分析在接受HAART的患者中观察到的眼部不良影响.
- 要突出眼部并发症的范围,从免疫恢复性脑膜炎到严重的疾病,如史蒂文斯-约翰逊综合征.
- 强调需要提高医生和患者对HAART相关眼睛毒性的认识.
主要方法:
- 案例报告系列详细介绍了三个不同的眼部不良影响病例.
- 记录了临床表现,诊断标准和治疗结果.
- 审查患者病史,包括HAART治疗方案和CD4计数.
主要成果:
- 案例1:26岁男性免疫恢复性脑膜炎 (IRU),成功用局部类固醇和循环症药物治疗.
- 案例2:在一个53岁的女性中,严重的皮质结膜炎,用滑剂治疗.
- 案例3:由于斯蒂文斯-约翰逊综合征导致的视力损失,14岁的女性,与内维拉平相关,突出显示了延迟干预的影响.
结论:
- 眼部不良反应虽然不常见,但在接受HAART的患者中可能会导致衰弱.
- 早期诊断和适当的管理对于维护视力至关重要.
- 进一步的研究和病例报告对于提高认识和指导临床实践至关重要.
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