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在严重的COVID-19期间,日本2型糖尿病患者的胰岛素需求相对较低:两起病例报告

Junpei Yamamoto¹, Hironobu Takahashi¹, Takaharu Saito¹

¹Division of Metabolism and Diabetes, Osaki Citizen Hospital, Osaki, JPN.

|November 29, 2023

概括

在2型糖尿病患者中,严重的COVID-19需要谨慎的胰岛素管理. 这项研究强调了日本患者的胰岛素需求较低,可能是由于种族和IL-6抑制.

科学领域:

内分泌学在内分泌学.
传染性疾病传染性疾病
临界护理医学临界护理医学

背景情况:

随着COVID-19的流行,二型糖尿病 (T2DM) 的患者受到严重影响,导致葡萄糖代谢恶化.
炎症,SARS-CoV-2感染,皮质类固醇使用和营养支持等因素有助于严重的COVID-19 T2DM患者的高血糖症.
高剂量的胰岛素通常是必要的,但影响需求的因素仍然不清楚.

研究的目的:

报告两名患有严重COVID-19的日本T2DM患者及其胰岛素需求.
与以前的文献相比,探索导致潜在较低胰岛素需求的因素.

主要方法:

两名T2DM患者的病例报告,患有严重的COVID-19,需要机械通风.
治疗包括德克萨米他和托西利祖马布 (IL-6受体抗体).
进行了静脉注射胰岛素治疗,并监测了胰岛素需求.

主要成果:

两位患者最初需要高剂量的静脉注射胰岛素 (高达1.83单位/千克/天).
随着呼吸状况的改善,停用德甲和停止输液管养,胰岛素需求显著降低.
获得了令人满意的血糖控制,患者仅用口服抗糖尿病药物出院.

结论:

患有严重COVID-19的日本T2DM患者的静脉注射胰岛素需求可能比之前报告的要低.
胰岛素敏感性和IL-6受体抗体的管理方面的种族差异可能会影响胰岛素需求.
在严重的COVID-19恢复期间,对T2DM患者来说,个性化血糖管理至关重要.

关键词:

根据COVID-19的情况,种族差异是种族的差异.一个IL-6受体抗体.胰岛素要求胰岛素要求 2 型糖尿病 2 型糖尿病

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