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核心结合因子急性髓性白血病患者中二次遗传异常的患病率和预后:米特尔曼数据库分析

Renzo Martin Chapilliquen Ramirez¹, Mariana Teresa de Jesus Corbacho Pachas¹, Richard Junior Zapata Dongo¹

¹Facultad de Medicina Humana, Universidad de Piura, Miraflores 15074, Lima, Peru.

World journal of oncology

|November 29, 2023

概括

核心结合因子急性髓性白血病 (CBF-AML) 与二次遗传异常,如del(7) 和三形22表明更糟糕的预后. 确定这些遗传因素对于开发针对CBF-AML患者的向疗法至关重要.

科学领域:

血液学血液学血液学
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

核心结合因子急性髓性白血病 (CBF-AML),特征为t(8;21) 或 inv(16),通常具有良好的预后.
然而,二次遗传异常可以显著恶化整体生存率 (OS) 和复发率.

研究的目的:

为了确定特异的二次分子和染色体异常在t(8;21) 和 inv(16) CBF-AML亚型.
评估这些异常对患者的预后影响.

主要方法:

来自米特尔曼数据库 (2011-2021) 的193个CBF-AML病例的分析.
对5年生存期的生存分析.
单变异和多变异的考克斯回归以确定独立的预后遗传因素.

主要成果:

在54.9%的病例中存在二次遗传异常.
德尔7) 和三形22与明显更糟糕的5年生存状况相关.
在单变量分析中,NRAS突变在t(8;21) 组中显示出更糟糕的生存状况,但在多变量分析中并不显著.

结论:

CBF-AML表现出异质细胞遗传学,在inv(16) 和t(8;21) 组之间没有显著的OS差异.
德尔7),三22和NRAS突变是CBF-AML的潜在预后标志物.
识别二次遗传发现对于预测预后和开发向疗法至关重要.

关键词:

严重急性严重急性染色体异常是一种染色体异常.核心约束因素核心约束因素在白血病中,白血病.骨髓状细胞是什么? 骨髓状细胞是什么?瘤基因是一种瘤基因.预测预后预测预测

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