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Updated: Jul 9, 2025

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
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转录因子ELF4通过激活IL1RN转录,抑制炎症TH17细胞活性,并诱导巨细胞M2极化来缓解炎症性肠病

Meiwan Cao1, Peiyu Chen1, Baoling Peng2

  • 1Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Frontiers in immunology
|November 29, 2023
PubMed
概括

这项研究揭示了ELF4 (E74类似因子4) 激活IL1RN转录,这有助于抑制炎症TH17细胞并促进M2巨细胞的两极分化,为炎症性肠病 (IBD) 提供了新的治疗策略.

关键词:
在 IL1RN 中, IL1RN 是在Th17细胞中.生物信息学分析分析疾病活动指数指数.炎症性肠病是一种炎症性肠病.炎症因素是炎症因素.巨细胞的M2极化转录调节器 ELF4 转录调节器 ELF4

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