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向与瘤相关的巨细胞:肺癌治疗的辅助策略

Lei Liu¹, Genwang Chen¹, Sisi Gong¹

¹Department of Laboratory Medicine, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Frontiers in immunology

|November 29, 2023

概括

与瘤相关的巨细胞 (TAMs) 驱动肺癌的进展和对治疗的抗性. 向TAM为改善癌症治疗提供了新的策略,特别是在与抗PD-1/PD-L1.1.等免疫疗法相结合时.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

肺癌仍然是全球癌症死亡的主要原因,通常是由于治疗耐药性.
瘤相关巨细胞 (TAMs) 是瘤微环境 (TME) 中的关键免疫细胞,它们显著影响肺癌的发展.
在肺癌中,TAMs调节免疫抑制,代谢重编程,血管生成,转移和神经生成.

研究的目的:

总结TAMs对肺癌进展的贡献机制.
详细阐述针对肺癌中TAMs的新型治疗策略.
讨论TAM向作为辅助疗法的潜力,特别是增强抗PD-1/PD-L1疗效.

主要方法:

文献综述和现有关于TAMs在肺癌中的研究的综合.
对TAM介导的瘤进展和治疗抵抗机制的分析.
评估当前和新兴的TAM向治疗策略及其组合潜力.

主要成果:

TAMs在促进肺癌方面发挥着多方面的作用,包括促进免疫抑制性TME和促进转移.
针对TAM的治疗策略包括抑制招募,重编程,耗尽和为药物输送进行工程.
将TAM向治疗与免疫治疗,化疗和放射治疗等现有治疗相结合,显示出有前途的协同效应.

结论:

向TAM代表了克服肺癌耐药性的有希望的治疗途径.
以TAM为中心的策略可以显著提高当前肺癌治疗的疗效,包括免疫检查点抑制剂,如抗PD-1/PD-L1.1.
对TAM向治疗的进一步研究有可能改善肺癌患者的治疗结果.

关键词:

在PD-1/PD-L1中.综合疗法综合疗法免疫疗法免疫疗法肺癌是一种肺癌.与瘤相关的巨细胞.

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