超重和肥胖COVID-19患者的SARS-CoV-2特定免疫反应
Therese Bredholt Onyango1, Fan Zhou1, Geir Bredholt2
1Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway.
Frontiers in immunology
|November 29, 2023
概括
肥胖和超重会加重COVID-19的严重程度,并导致对SARS-CoV-2感染的免疫反应更强,但潜在效率更低. 超重的个体表现出过度反应的免疫系统,突出显示了他们对疫苗接种的风险群体地位.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 肥胖是严重呼吸道感染的已知的危险因素,包括COVID-19.
- 了解与体重指数 (BMI) 相关的SARS-CoV-2的长期免疫反应对于公共卫生战略至关重要.
研究的目的:
- 调查肥胖和超重状态对感染后长达18个月的SARS-CoV-2感染的幽默和细胞免疫反应的影响.
- 评估BMI,COVID-19严重程度以及SARS-CoV-2特定免疫反应的大小和特征之间的相关性.
主要方法:
- 对274名SARS-CoV-2患者进行前性研究,按BMI (正常,超重,肥胖) 分类.
- 测量SARS-CoV-2特定的IgG,IgA,IgM和中和抗体标位.
- 对记忆B细胞,T细胞反应 (IFN-γ,IL-2分泌) 和T细胞受体测序的分析.
主要成果:
- 较高的BMI与增加的COVID-19严重程度相关.
- 与正常体重患者相比,超重和肥胖患者表现出更强的幽默和细胞免疫反应.
- 体重指数,年龄和COVID-19的严重程度是SARS-CoV-2免疫反应升高的独立预测因素. 在超重/肥胖患者中观察到独特的SARS-CoV-2特异性T细胞克隆型的比例增加.
- 在所有BMI群体中,COVID-19疫苗接种提高了免疫反应,正常体重个体的效果更为明显.
结论:
- 超重和肥胖的人体验更严重的COVID-19并显示过度反应性免疫反应感染后.
- 这些发现强调了优先考虑超重和肥胖个体进行COVID-19疫苗接种的重要性,因为他们的风险概况增加了.
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