三级淋巴体结构作为器官特异性免疫损伤的局部延续者:对狼性炎的影响
Meiying Wang1,2,3, Snehin Rajkumar3, Yupeng Lai1
1Department of Rheumatology and Immunology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Frontiers in immunology
|November 29, 2023
概括
三级淋巴状结构 (TLS) 在狼性炎中形成脏,恶化炎症和疾病. 准TLS可能为狼性炎提供新的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 免疫细胞在炎症期间在非淋巴细胞组织中形成三级淋巴体结构 (TLS).
- TLS类似于二级淋巴体器官,并与自身免疫性疾病有关.
- 狼性炎是一种严重的自身免疫性疾病,影响脏.
研究的目的:
- 为了研究TLS在狼性炎的发病过程中的作用.
- 为了确定参与狼性炎脏中TLS形成的因素.
- 为了将TLS存在与疾病严重程度和治疗反应相关联.
主要方法:
- 从狼性炎患者和动物模型中分析脏活检.
- 评估免疫细胞聚合物,淋巴组织诱导/组织细胞和细胞通信.
- 测量化基因 (例如CXCL13) 和与白细胞迁移和血管化相关的分子.
- 评估与TLS存在有关的疾病活动,慢性指数和治疗反应.
主要成果:
- TLS的特征是淋巴结状结构和基因特征,存在于狼性炎脏中.
- TLS的形成与增加的淋巴细胞产生的化学因子和白细胞迁移分子有关.
- 脏TLS与严重的管间位炎症,较高的疾病活性/慢性和治疗结果差相关.
- 通过促进自身反应性B细胞存活,自身抗体产生和表位细胞扩散,TLS有助于病变发生.
- 针对TLS组件的治疗干预措施 (例如,抗CXCL13,Cenerimod) 在动物模型中减少了TLS和改善了狼性炎.
结论:
- TLS在狼性炎的发病过程中发挥着重要作用.
- TLS与严重的脏炎症和狼性炎的不良预后有关.
- 向TLS代表了狼性炎的潜在治疗策略.
- 需要进一步的研究,以充分理解TLS机制,并开发非侵入性检测方法.
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