相关实验视频

Updated: Jul 9, 2025

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
09:32

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

Published on: October 15, 2021

12.2K

开发一种半自动化的MHC相关蛋白组学 (MAPPs) 方法,使用基于斯特雷普塔维丁珠的免疫亲和捕获和纳米LC-MS/MS来支持药物开发中的免疫性风险评估

M Violet Lee1, Ola M Saad1, Sylvia Wong1

  • 1Department of Bioanalytical Sciences, Genentech, Inc., South San Francisco, CA, United States.

Frontiers in immunology
|November 29, 2023
PubMed
概括

我们开发了一种半自动化主要基因相容性复合体 (MHC) 相关蛋白质组 (MAPPs) 方法来评估生物治疗免疫性. 这种改进的方法提高了识别T细胞表位的可复制性和灵敏性,有助于药物开发.

关键词:
这就是LC-MS.与MHC相关的蛋白质组 (MAPPs)生物治疗药物 生物治疗药物免疫亲和感捕获 免疫亲和感捕获免疫性风险评估免疫性风险评估在体外/外生体内.主要组织相容性复合物II类 (MHC II)斯特雷普塔维丁磁性珠子

更多相关视频

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

15.0K
Peptide and Protein Quantification Using Automated Immuno-MALDI iMALDI08:57

Peptide and Protein Quantification Using Automated Immuno-MALDI iMALDI

Published on: August 18, 2017

8.0K

相关概念视频

Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
6.5K