相关实验视频

Updated: Jul 9, 2025

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

结直肠癌的外科手术期间免疫检查点抑制:最近的进展和未来的方向

Jiao-Ting Chen¹, Yu-Wen Zhou¹, Ting-Rui Han²

¹Department of Colorectal Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in immunology

|November 29, 2023

概括

术后免疫疗法对结肠直肠癌 (CRC) 患者有希望,改善了那些微卫星高度不稳定/缺陷不匹配修复 (MSI-H/dMMR) 患者的治疗结果,甚至有些人患有不匹配修复能力/微卫星稳定 (pMMR/MSS) 疾病.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
胃肠道手术胃肠道手术

背景情况:

手术切除对于结肠直肠癌至关重要,但对于晚期或转移性病例并不总是可行或完全有效.
周围手术治疗可以降低瘤的发展阶段,并减少CRC的复发/转移.
免疫检查点抑制剂 (ICI) 在MSI-H/dMMRCRC中有效,但在pMMR/MSSCRC中效果较差,尽管存在例外.

研究的目的:

审查各种免疫疗法组合在术后CRC治疗中的疗效和安全性.
探索基于免疫治疗的术后CRC疗法患者选择的预测因素.
突出 CRC 中术后免疫治疗的未来研究方向.

主要方法:

在CRC中进行术后免疫治疗临床试验的综合文献综述.
从涉及免疫疗法组合的试验中分析疗效和安全数据.
综合当前关于CRC外科设置中的免疫治疗的研究.

主要成果:

在MSI-H/dMMR CRC中,ICI提供了显著的生存益处和安全性.
新出现的证据表明,免疫疗法在pMMR/MSS CRC和某些dMMR/MSI-H病例中具有抗性的潜在好处.
越来越多地研究涉及免疫疗法,化疗和放射治疗的组合疗法.

结论:

对于CRC,外科期免疫疗法策略正在发展.
识别预测生物标志物对于优化患者选择和治疗反应至关重要.
需要进一步的研究来完善免疫疗法组合,并扩大其在CRC中的应用.

关键词:

结肠直肠癌是什么意思免疫检查点抑制抑制免疫检查点抑制微卫星的不稳定性很高.微卫星稳定的微卫星不匹配维修缺陷缺陷不匹配的维修能力不匹配的维修能力.在外科手术期间进行治疗.

更多相关视频

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...