基于脂质纳米系统的局部药物输送用于治疗类风湿性关节炎:概述
Komal Diliprao Dhule1, Tanaji Dilip Nandgude1
1Dr. D. Y. Patil Institute of Pharmaceutical Science and Research, Pimpri, Pune 411018, Department of Pharmaceutics, Pune, Maharashtra, India.
Advanced pharmaceutical bulletin
|November 29, 2023
概括
类风湿性关节炎 (RA) 治疗面临着药物副作用和低生物可用性的挑战. 局部纳米载体系统为改善药物输送和患者在RA管理中的遵守提供了一个有希望的替代方案.
科学领域:
- 制药科学 制药科学
- 生物技术是生物技术.
- 类风湿病学 类风湿病学
背景情况:
- 类风湿性关节炎 (RA) 缺乏治愈方法,目前的治疗方法如NSAIDs和DMARDs造成不良影响和患者不良遵守.
- 传统的RA药物输送方法存在一些问题,如高的第一通代谢,快速清除和低生物可用性.
- 角层对局部治疗的有效局部药物透具有重大障碍.
研究的目的:
- 审查基于脂质的纳米载体系统,用于局部抗风湿性药物输送.
- 探索与类风湿性关节炎研究相关的活体动物模型.
- 提供在该领域授予的专利的概述.
主要方法:
- 关于用于局部药物输送的纳米载体技术的文献综述.
- 在类风湿性关节炎研究中使用的活体动物模型的分析.
- 对抗风湿性纳米载体应用的专利景观的调查.
主要成果:
- 基于脂质的纳米载体显示出增强抗风湿药物局部递送的潜力.
- 纳米载体系统提供生物相容性,稳定性和减少细胞毒性.
- 该审查综合了关于纳米载体应用,动物模型和专利数据的信息.
结论:
- 局部纳米载体系统是克服传统RA治疗局限性的可行策略.
- 这种方法可以提高药物的生物可用性,提高患者的遵守性,并使特定地点的行动成为可能.
- 纳米载体技术的进一步研究和开发有望为先进的RA疗法提供前景.
更多相关视频
相关概念视频
Drug Delivery: Miscellaneous Routes
357
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
357
Drug Delivery: Overview
296
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
296


