亚种群治疗效应模式图谱分析:远程无复发生存预后模型,以估计三阴性乳腺癌中延迟辅助化疗启动效应的预后模型
Zaida Morante1,2, Yomali Ferreyra3, Joseph A Pinto4
1Departamento de Medicina Oncológica, Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru.
Frontiers in oncology
|November 29, 2023
概括
推迟三阴性乳腺癌 (TNBC) 辅助化疗显著增加复发风险,特别是在高风险患者中. 及时治疗对于改善TNBC患者的远程无复发生存率 (DRFS) 是至关重要的.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 生物统计学 生物统计学
背景情况:
- 三阴性乳腺癌 (TNBC) 是一种具有不良预后的侵袭性亚型.
- 延迟辅助化疗 (TTC) 与较差的远程无复发生存率 (DRFS) 有关.
研究的目的:
- 开发和验证TNBC风险分层的预后模型.
- 评估延迟TTC对不同TNBC风险子组DRFS的影响.
主要方法:
- 对687名接受辅助化疗的TNBC患者的分析.
- 使用考克斯回归和STEPP分析开发了两种预后模型.
- 将风险分组分为层次,并根据TTC时间对10年DRFS进行比较.
主要成果:
- 年龄 (≥70岁),晚期瘤阶段 (pT3-T4) 和淋巴结转移 (pN2-N3) 是较高风险的重要预测因素.
- 延迟的TTC (>30天) 减少了10年的DRFS总体17.5%.
- 延迟TTC的负面影响在高危子组中最为明显,十年DRFS减少了53.3%.
结论:
- 开发了两个预后模型来分类TNBC风险.
- 延迟辅助化疗显著增加了高风险TNBC患者的复发风险,特别是晚期疾病的老年人.
- 尽量减少治疗延迟的努力对于改善TNBC的结果至关重要,特别是在高风险人群中.
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