管理模式和与药物相关的危害及其预测因素在结直肠癌患者:一个机构基础的回顾性研究
Belayneh Kefale1, Melaku Tadege Engidaw2, Desalegn Tesfa2
1Clinical Pharmacy Unit and Research team, Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Frontiers in oncology
|November 29, 2023
概括
与药物相关的危害 (MRH) 影响了超过一半的结直肠癌 (CRC) 患者,晚期,并发症和多药是关键预测因素. 改善临床药房服务对于优化CRC患者护理至关重要.
科学领域:
- 在瘤学瘤学.
- 临床药房 临床药房
- 药物监督 药物监督 药物监督
背景情况:
- 在接受化疗的结直肠癌 (CRC) 患者中,关于与药物相关的危害 (MRH) 的数据有限.
- 了解这些危害对于优化CRC管理中的治疗和患者结果至关重要.
研究的目的:
- 在接受化疗的结直肠癌 (CRC) 患者中调查与药物相关危害 (MRH) 的患病率和预测因素.
- 在这个患者群体中确定与MRH相关的特定风险因素.
主要方法:
- 一项基于注册的回顾性队列研究在冈达尔大学综合专门医院进行.
- 审查了2017-2021年期间治疗的143名CRC患者的医疗记录.
- 使用后勤回归分析来确定MRH的独立预测因素.
主要成果:
- 超过一半 (53.1%) 的CRC患者经历了MRH,平均每位患者的伤害为2.45.
- 常见的MRH包括需要额外的药物治疗,次治疗剂量,药物相互作用和不良药物反应.
- 独立预测MRH的因素是癌症晚期 (第四阶段),并发症,并发症以及使用五种或更多药物.
结论:
- 与药物相关的危害在CRC患者中很普遍,与疾病阶段,并发症,并发症和多药性相关.
- 通常使用基于甲的疗法.
- 加强临床药房服务对于优化药物治疗和缓解CRC患者的MRH至关重要.
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