驱动基因突变与老年肺腺癌的临床病理特征之间的关系
Xia Liu1, Guopeng Jiang1, Xuefei Sun1
1Department of Thoracic Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Frontiers in oncology
|November 29, 2023
概括
老年肺腺癌患者经常有多个基因突变,EGFR是最常见的. 综合基因检测可以改善针对性治疗结果和这群人的生活质量.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 老年病的医生 老年病的医生
背景情况:
- 肺腺癌 (LUAD) 是老年人常见的一种癌症,老年人经常经历较差的治疗耐受性.
- 皮表皮生长因子受体 (EGFR) 和形淋巴瘤激酶 (ALK) 氨酸激酶抑制剂 (TKIs) 提供比化疗更好的结果,但由于基因检测率低,在老年患者中未得到充分利用.
- 了解老年LUAD患者的突变概况对于优化向治疗至关重要.
研究的目的:
- 在60岁及以上的患者中研究LUAD驱动基因的突变特征.
- 探索这些遗传突变与老年LUAD患者临床病理特征之间的关系.
主要方法:
- 下一代测序 (NGS) 用于分析手术后组织样本中的基因突变,来自275名60岁以上的LUAD患者.
- 这项研究研究了十个关键基因的突变:EGFR,KRAS,ALK,ROS1,RET,MET,BRAF,HER2,PIK3CA和NRAS.
主要成果:
- 在老年LUAD患者中观察到高突变率90.18%,EGFR突变是最常见的 (69.82%).
- 同时发生的突变在1563%的EGFR突变患者中被发现. 像L858R和exon19删除这样的特定突变占主导地位.
- 在女性和非吸烟者中,EGFR突变更为常见,而在男性和吸烟者中,KRAS突变更为普遍. BRAF突变显示出对右肺的偏好.
结论:
- 年长的LUAD患者呈现出多样化且经常同时发生的基因突变.
- 针对多个基因突变的综合性NGS可以促进及时有效的向治疗.
- 通过广泛的基因查来改善向治疗可以提高老年LUAD患者的生活质量.
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