案例报告:一种新的FGFR1融合在急性B-淋巴细胞白血病中,通过RNA测序确定其序列
Zhibo Zhang1,2, Yiyan Zhu1,2, Zheng Wang3
1Jiangsu Institute of Hematology, Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China.
Frontiers in oncology
|November 29, 2023
概括
这项研究确定了第一个KIF5B-FGFR1融合在急性B-淋巴细胞白血病,一种罕见的血液恶性瘤. 这一发现扩大了在8p11骨髓增殖综合征中已知的遗传改变.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
背景情况:
- 8p11骨髓增殖综合征是一种罕见的,具有攻击性的血液性恶性瘤.
- 它通常是由涉及FGFR1基因的各种转位引起的.
相关概念视频
02:24Ribosome Profiling
3.5K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.5K
02:28Leaky Scanning
5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K