病例报告:深度分子缓解后两个单独的CD19向的化学抗原受体T细胞疗法不能防止疾病复发在费城染色体阳性急性淋巴细胞白血病
Yu Tang1, Xiaoming Fei2, Xianqiu Yu2
1Department of Rheumatology and Immunology, Affiliated Hospital of Jiangsu University, Zhengjiang, Jiangsu, China.
Frontiers in oncology
|November 29, 2023
概括
针对CD19的重复CAR T细胞治疗可以在初始CAR T细胞治疗和alo-SCT后对复发的费城染色体阳性急性淋巴细胞白血病 (Ph + ALL) 有效. 这一案例突出了挑战Ph+ALL案例的潜在救援选择.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 费城染色体阳性急性淋巴细胞白血病 (Ph+ ALL) 是一种具有挑战性的复发管理的攻击性B细胞恶性瘤.
- 目前对复发的Ph+ALL的救援选择包括全源干细胞移植 (allo-SCT) 和CD19向的仿真抗原受体T细胞 (CAR T细胞) 治疗.
- 对接受alo-SCT和多重CAR T细胞治疗的患者的最佳管理策略尚不清楚.
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